Diphenylphosphine oxide is commonly used in the preparation of triphenylphosphine oxide, alkenyl diphenylphosphine oxide, addition to alkynes, and Wittig-Horner reaction reagents. The synthetic Ph2P(O)H of diphenylphosphine derivatives is coupled with aryl trifluoromesylate, and the reduction of phosphine oxides to diphenylaryl phosphine is a common chiral ligand. Ph2P(O)H reacts with TMSCl to produce trimethylsiloxy-diphenylphosphine, which reacts with halogenated olefin to produce alkenyl diphenylphosphine oxide. Addition to alkynes The addition of diphenylphosphine oxide to alkynes in the presence of metal catalysis produces highly stereospecific olefin compounds. Addition to olefin under microwave conditions, the addition reaction between diphenylphosphine oxide and olefin can occur, and the reaction does not require any solvent and catalyst. Reaction with difluoro-dichloromethane Ph2P(O)H reacts with difluoro-dichloromethane to produce difluoromethyldiphenylphosphine oxide, which further reacts with aldehydes or ketones to form 1, 1-difluoroalkenes.

Diphenyl phosphorus oxide is a new type of organic phosphorus flame retardant product, which can be used as flame retardant for metal materials and other high-end materials in industry.